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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDK9
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CDK9

Gene description

Cyclin-dependent kinase 9

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA006738 , CAB004216
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA006738
CAB004216

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong nuclear staining was observed in most cancers. Hepatocellular carcinomas displayed weaker positivity than cholangiocarcinomas that were generally strongly stained.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells showed strong nuclear immunoreactivity.

GENE INFORMATION

Gene name

CDK9 (HGNC Symbol)

Synonyms

C-2k, CDC2L4, PITALRE, TAK

Description

Cyclin-dependent kinase 9 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

127785679 - 127790787

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136807 (version 83.38)

Entrez gene

1025

UniProt

P50750 (UniProt - Evidence at protein level)

neXtProt

NX_P50750

Antibodypedia

CDK9 antibodies

PROTEIN BROWSER

CDK9-001
CDK9-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK9-001
ENSP00000362361
ENST00000373264
P50750 [Direct mapping]
Cyclin-dependent kinase 9
A0A024R880 [Target identity:100%; Query identity:100%]
Cyclin-dependent kinase 9 (CDC2-related kinase), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006282 [regulation of DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008023 [transcription elongation factor complex]
GO:0008024 [positive transcription elongation factor complex b]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0017069 [snRNA binding]
GO:0031056 [regulation of histone modification]
GO:0031297 [replication fork processing]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0042493 [response to drug]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071345 [cellular response to cytokine stimulus]
GO:1900364 [negative regulation of mRNA polyadenylation]
GO:1903839 [positive regulation of mRNA 3'-UTR binding]
GO:2001168 [positive regulation of histone H2B ubiquitination]
Show all
372 aa
42.8 kDa
No 0
CDK9-005
ENSP00000395872
ENST00000421939
X6RE90 [Direct mapping]
Cyclin-dependent kinase 9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
194 aa
19.5 kDa
No 0

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