Expression of TOR1B in cancer - Summary - The Human Protein Atlas

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TOR1B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TOR1B
Gene description	Torsin family 1, member B (torsin B)
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA013403 , HPA013697 , CAB022709
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013403	HPA013697	CAB022709

GENE INFORMATION
Gene name	TOR1B (HGNC Symbol)
Synonyms	DQ1, MGC4386
Description	Torsin family 1, member B (torsin B) (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	129803153 - 129811281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136816 (version 83.38)
Entrez gene	27348
UniProt	O14657 (UniProt - Evidence at protein level)
neXtProt	NX_O14657
Antibodypedia	TOR1B antibodies

PROTEIN BROWSER

TOR1B-001	TOR1B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TOR1B-001 ENSP00000259339 ENST00000259339	O14657 [Direct mapping] Torsin-1B Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006986 [response to unfolded protein] GO:0007029 [endoplasmic reticulum organization] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0031965 [nuclear membrane] GO:0051085 [chaperone mediated protein folding requiring cofactor] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular exosome] GO:0071763 [nuclear membrane organization] Show all	336 aa 38 kDa	Yes	0
TOR1B-003 ENSP00000411912 ENST00000427860	H0Y7C8 [Direct mapping] Torsin-1B Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0007029 [endoplasmic reticulum organization] Show all	141 aa 15.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.