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DAB2IP

GENERAL INFORMATION

Gene name

 DAB2IP

Gene description

 DAB2 interacting protein

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HaCaT)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DAB2IP (HGNC Symbol)

Synonyms

 AF9Q34, AIP1, DIP1/2, KIAA1743

Description

 DAB2 interacting protein (HGNC Symbol)

Entrez gene summary

 DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

Chromosome

 9

Cytoband

 q33.2

Chromosome location (bp)

 121567057 - 121785530

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136848 (version 83.38)

Entrez gene

 153090

UniProt

 Q5VWQ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5VWQ8

Antibodypedia

 DAB2IP antibodies

PROTEIN BROWSER
DAB2IP-001
DAB2IP-004
DAB2IP-005
DAB2IP-009
DAB2IP-010
DAB2IP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAB2IP-001
ENSP00000377872
ENST00000394340
F8WA47 [Direct mapping]
Disabled homolog 2-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016525 [negative regulation of angiogenesis]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 291 aa
33.1 kDa 		No 0
DAB2IP-004
ENSP00000310827
ENST00000309989
Q5VWQ8 [Direct mapping]
Disabled homolog 2-interacting protein
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005096 [GTPase activator activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006927 [transformed cell apoptotic process]
GO:0006954 [inflammatory response]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007252 [I-kappaB phosphorylation]
GO:0007257 [activation of JUN kinase activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010976 [positive regulation of neuron projection development]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016525 [negative regulation of angiogenesis]
GO:0017124 [SH3 domain binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration]
GO:0021819 [layer formation in cerebral cortex]
GO:0030139 [endocytic vesicle]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0032403 [protein complex binding]
GO:0032809 [neuronal cell body membrane]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034260 [negative regulation of GTPase activity]
GO:0035148 [tube formation]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0035591 [signaling adaptor activity]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038026 [reelin-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043254 [regulation of protein complex assembly]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity]
GO:0044257 [cellular protein catabolic process]
GO:0044300 [cerebellar mossy fiber]
GO:0044301 [climbing fiber]
GO:0045087 [innate immune response]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051721 [protein phosphatase 2A binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
GO:0070317 [negative regulation of G0 to G1 transition]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0072577 [endothelial cell apoptotic process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090129 [positive regulation of synapse maturation]
GO:1900006 [positive regulation of dendrite development]
GO:1900744 [regulation of p38MAPK cascade]
GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990032 [parallel fiber]
GO:1990597 [AIP1-IRE1 complex]
GO:2000599 [negative regulation of cyclin catabolic process]
GO:2001224 [positive regulation of neuron migration]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 1065 aa
117.7 kDa 		No 0
DAB2IP-005
ENSP00000409327
ENST00000436835
F6R503 [Direct mapping]
Disabled homolog 2-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016525 [negative regulation of angiogenesis]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 229 aa
26.3 kDa 		No 0
DAB2IP-009
ENSP00000386183
ENST00000408936
Q5VWQ8 [Direct mapping]
Disabled homolog 2-interacting protein
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005096 [GTPase activator activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006927 [transformed cell apoptotic process]
GO:0006954 [inflammatory response]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007252 [I-kappaB phosphorylation]
GO:0007257 [activation of JUN kinase activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010976 [positive regulation of neuron projection development]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016525 [negative regulation of angiogenesis]
GO:0017124 [SH3 domain binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration]
GO:0021819 [layer formation in cerebral cortex]
GO:0030139 [endocytic vesicle]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0032403 [protein complex binding]
GO:0032809 [neuronal cell body membrane]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034260 [negative regulation of GTPase activity]
GO:0035148 [tube formation]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0035591 [signaling adaptor activity]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038026 [reelin-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043254 [regulation of protein complex assembly]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity]
GO:0044257 [cellular protein catabolic process]
GO:0044300 [cerebellar mossy fiber]
GO:0044301 [climbing fiber]
GO:0045087 [innate immune response]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051721 [protein phosphatase 2A binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
GO:0070317 [negative regulation of G0 to G1 transition]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0072577 [endothelial cell apoptotic process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090129 [positive regulation of synapse maturation]
GO:1900006 [positive regulation of dendrite development]
GO:1900744 [regulation of p38MAPK cascade]
GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990032 [parallel fiber]
GO:1990597 [AIP1-IRE1 complex]
GO:2000599 [negative regulation of cyclin catabolic process]
GO:2001224 [positive regulation of neuron migration]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 1189 aa
131.6 kDa 		No 0
DAB2IP-010
ENSP00000362887
ENST00000373782
H0Y3A3 [Direct mapping]
Disabled homolog 2-interacting protein
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0016525 [negative regulation of angiogenesis]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 1069 aa
118.1 kDa 		No 0
DAB2IP-201
ENSP00000259371
ENST00000259371
Q5VWQ8 [Direct mapping]
Disabled homolog 2-interacting protein
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005096 [GTPase activator activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006927 [transformed cell apoptotic process]
GO:0006954 [inflammatory response]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007252 [I-kappaB phosphorylation]
GO:0007257 [activation of JUN kinase activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010976 [positive regulation of neuron projection development]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016525 [negative regulation of angiogenesis]
GO:0017124 [SH3 domain binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration]
GO:0021819 [layer formation in cerebral cortex]
GO:0030139 [endocytic vesicle]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0032403 [protein complex binding]
GO:0032809 [neuronal cell body membrane]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034260 [negative regulation of GTPase activity]
GO:0035148 [tube formation]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0035591 [signaling adaptor activity]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038026 [reelin-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043254 [regulation of protein complex assembly]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity]
GO:0044257 [cellular protein catabolic process]
GO:0044300 [cerebellar mossy fiber]
GO:0044301 [climbing fiber]
GO:0045087 [innate immune response]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051721 [protein phosphatase 2A binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
GO:0070317 [negative regulation of G0 to G1 transition]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0072577 [endothelial cell apoptotic process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090129 [positive regulation of synapse maturation]
GO:1900006 [positive regulation of dendrite development]
GO:1900744 [regulation of p38MAPK cascade]
GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990032 [parallel fiber]
GO:1990597 [AIP1-IRE1 complex]
GO:2000599 [negative regulation of cyclin catabolic process]
GO:2001224 [positive regulation of neuron migration]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 1132 aa
125 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.