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Malignant carcinoids, malignant melanomas along with several cases of malignant gliomas exhibited moderate to strong cytoplasmic immunoreactivity. Remaining cancer tissues were in general negative.
GENE INFORMATION
Gene name
STXBP1 (HGNC Symbol)
Synonyms
hUNC18, MUNC18-1, rbSec1, UNC18
Description
Syntaxin binding protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]