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USP20

GENERAL INFORMATION

Gene name

 USP20

Gene description

 Ubiquitin specific peptidase 20

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA006287
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), renal cancer (favourable), colorectal cancer (unfavourable), endometrial cancer (favourable) and cervical cancer (favourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
Colorectal cancer p<0.001
Endometrial cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006287

GENE INFORMATION

Gene name

 USP20 (HGNC Symbol)

Synonyms

 KIAA1003

Description

 Ubiquitin specific peptidase 20 (HGNC Symbol)

Entrez gene summary

 This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 129834698 - 129881838

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136878 (version 83.38)

Entrez gene

 10868

UniProt

 Q9Y2K6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2K6

Antibodypedia

 USP20 antibodies

PROTEIN BROWSER
USP20-001
USP20-002
USP20-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP20-001
ENSP00000361506
ENST00000372429
Q9Y2K6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 20
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006897 [endocytosis]
GO:0008270 [zinc ion binding]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
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 914 aa
102 kDa 		No 0
USP20-002
ENSP00000351122
ENST00000358355
Q9Y2K6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 20
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006897 [endocytosis]
GO:0008270 [zinc ion binding]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 914 aa
102 kDa 		No 0
USP20-003
ENSP00000313811
ENST00000315480
Q9Y2K6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 20
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006897 [endocytosis]
GO:0008270 [zinc ion binding]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 914 aa
102 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.