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ATP6V1G1

GENERAL INFORMATION

Gene name

 ATP6V1G1

Gene description

 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB004615
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB004615

GENE INFORMATION

Gene name

 ATP6V1G1 (HGNC Symbol)

Synonyms

 ATP6G, ATP6G1, ATP6GL, ATP6J, DKFZp547P234, Vma10

Description

 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q32

Chromosome location (bp)

 114587746 - 114598373

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136888 (version 83.38)

Entrez gene

 9550

UniProt

 O75348 (UniProt - Evidence at protein level)

neXtProt

 NX_O75348

Antibodypedia

 ATP6V1G1 antibodies

PROTEIN BROWSER
ATP6V1G1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V1G1-001
ENSP00000363162
ENST00000374050
O75348 [Direct mapping]
V-type proton ATPase subunit G 1
A0A024R883 [Target identity:100%; Query identity:100%]
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1, isoform CRA_a
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0008286 [insulin receptor signaling pathway]
GO:0008553 [hydrogen-exporting ATPase activity, phosphorylative mechanism]
GO:0015992 [proton transport]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0016887 [ATPase activity]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
GO:1902600 [hydrogen ion transmembrane transport]
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 118 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.