Expression of GABBR2 in cancer - Summary - The Human Protein Atlas

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GABBR2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GABBR2
Gene description	Gamma-aminobutyric acid (GABA) B receptor, 2
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, thyroid cancer, urothelial cancer)
HPA (cell line):	Cell line enhanced (BJ, HUVEC TERT2, U-138 MG)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA013820 , HPA031684
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, thyroid cancer, urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013820	HPA031684

GENE INFORMATION
Gene name	GABBR2 (HGNC Symbol)
Synonyms	GABABR2, GPR51, GPRC3B, HG20
Description	Gamma-aminobutyric acid (GABA) B receptor, 2 (HGNC Symbol)
Entrez gene summary	The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
Chromosome	9
Cytoband	q22.33
Chromosome location (bp)	98288082 - 98709197
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136928 (version 83.38)
Entrez gene	9568
UniProt	O75899 (UniProt - Evidence at protein level)
neXtProt	NX_O75899
Antibodypedia	GABBR2 antibodies

PROTEIN BROWSER

GABBR2-001	GABBR2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GABBR2-001 ENSP00000259455 ENST00000259455	O75899 [Direct mapping] Gamma-aminobutyric acid type B receptor subunit 2 H9NIL8 [Target identity:100%; Query identity:100%] Gamma-aminobutyric acid (GABA) B receptor, 2, isoform CRA_b; Gamma-aminobutyric acid B receptor 2 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004965 [G-protein coupled GABA receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0038039 [G-protein coupled receptor heterodimeric complex] GO:0043005 [neuron projection] GO:0045211 [postsynaptic membrane] Show all	941 aa 105.8 kDa	Yes	7
GABBR2-008 ENSP00000489352 ENST00000634457		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	183 aa 20.8 kDa	No	5

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.