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A majority of cancers showed weak to moderate granular cytoplasmic staining. Cases of squamous cell carcinomas, basal cell carcinomas and urothelial cancers were strongly stained. Many lymphomas, liver and renal cancers were negative.
A majority of cancer cells displayed moderate cytoplasmic immunoreactivity. Additional nuclear staining was observed in a few cases. Several lymphomas, colorectal and prostate cancers were strongly positive.
GENE INFORMATION
Gene name
GOLGA1 (HGNC Symbol)
Synonyms
golgin-97, MGC33154
Description
Golgin A1 (HGNC Symbol)
Entrez gene summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]