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NCBP1

GENERAL INFORMATION

Gene name

 NCBP1

Gene description

 Nuclear cap binding protein subunit 1, 80kDa

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA042411 , HPA049031
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NCBP1 (HGNC Symbol)

Synonyms

 CBP80, NCBP, Sto1

Description

 Nuclear cap binding protein subunit 1, 80kDa (HGNC Symbol)

Entrez gene summary

 The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.33

Chromosome location (bp)

 97633626 - 97673748

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136937 (version 83.38)

Entrez gene

 4686

UniProt

 Q09161 (UniProt - Evidence at protein level)

neXtProt

 NX_Q09161

Antibodypedia

 NCBP1 antibodies

PROTEIN BROWSER
NCBP1-001
NCBP1-004
NCBP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCBP1-001
ENSP00000364289
ENST00000375147
Q09161 [Direct mapping]
Nuclear cap-binding protein subunit 1
A0A024R179 [Target identity:100%; Query identity:100%]
Nuclear cap binding protein subunit 1, 80kDa, isoform CRA_a
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Transporters
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000339 [RNA cap binding]
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003723 [RNA binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005845 [mRNA cap binding complex]
GO:0005846 [nuclear cap binding complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006406 [mRNA export from nucleus]
GO:0006446 [regulation of translational initiation]
GO:0008334 [histone mRNA metabolic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016070 [RNA metabolic process]
GO:0030529 [ribonucleoprotein complex]
GO:0031047 [gene silencing by RNA]
GO:0031124 [mRNA 3'-end processing]
GO:0031442 [positive regulation of mRNA 3'-end processing]
GO:0034660 [ncRNA metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045292 [mRNA cis splicing, via spliceosome]
GO:0050434 [positive regulation of viral transcription]
GO:0098789 [pre-mRNA cleavage required for polyadenylation]
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 790 aa
91.8 kDa 		No 0
NCBP1-004
ENSP00000364272
ENST00000375130
X6R941 [Direct mapping]
Nuclear cap-binding protein subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000339 [RNA cap binding]
GO:0005488 [binding]
GO:0005846 [nuclear cap binding complex]
GO:0016070 [RNA metabolic process]
GO:0045292 [mRNA cis splicing, via spliceosome]
GO:0051028 [mRNA transport]
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 155 aa
18.4 kDa 		No 0
NCBP1-201
ENSP00000487569
ENST00000629069
F2Z2T1 [Direct mapping]
Nuclear cap-binding protein subunit 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000339 [RNA cap binding]
GO:0005488 [binding]
GO:0005846 [nuclear cap binding complex]
GO:0045292 [mRNA cis splicing, via spliceosome]
GO:0051028 [mRNA transport]
Show all
 82 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.