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Most malignancies displayed moderate cytoplasmic staining. Several endometrial cancers were strongly stained. Malignant lymphomas, lung and squamous cell carcinomas in skin as well as several gastric cancers were weakly stained or negative.
GENE INFORMATION
Gene name
CTSV (HGNC Symbol)
Synonyms
CTSL2, CTSU
Description
Cathepsin V (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]