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General cytoplasmic expression, including nuclear abundance in subset of tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Sub cellular location is contradicted by external data. Pending external verification.
Most basal cell carcinomas in skin and a few cases of pancreatic cancers showed strong positivity. Cancer cells in general displayed weak to moderate cytoplasmic immunoreactivity often combined with nucleolar positivity. A majority of gliomas, renal and prostate cancers were negative.
GENE INFORMATION
Gene name
DSCC1 (HGNC Symbol)
Synonyms
DCC1, hDCC1, MGC5528
Description
DNA replication and sister chromatid cohesion 1 (HGNC Symbol)
Entrez gene summary
CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]