We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
NOV
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

NOV

Gene description

Nephroblastoma overexpressed

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ hTERT+, U-2197)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in adrenal gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA019684 , CAB034423
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA019684
CAB034423

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of prostate cancers displayed moderate to strong cytoplasmic and membranous staining. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few melanomas, prostate and cervical cancers showed moderate to strong cytoplasmic positivity. Other cancer tissues were negative.

GENE INFORMATION

Gene name

NOV (HGNC Symbol)

Synonyms

CCN3, IGFBP9

Description

Nephroblastoma overexpressed (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]

Chromosome

8

Cytoband

q24.12

Chromosome location (bp)

119416306 - 119424353

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136999 (version 83.38)

Entrez gene

4856

UniProt

P48745 (UniProt - Evidence at protein level)

neXtProt

NX_P48745

Antibodypedia

NOV antibodies

PROTEIN BROWSER

NOV-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NOV-001
ENSP00000259526
ENST00000259526
P48745 [Direct mapping]
Protein NOV homolog
A0A024R9J4 [Target identity:100%; Query identity:100%]
Nephroblastoma overexpressed gene, isoform CRA_a
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001558 [regulation of cell growth]
GO:0002062 [chondrocyte differentiation]
GO:0005112 [Notch binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005737 [cytoplasm]
GO:0005921 [gap junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0010468 [regulation of gene expression]
GO:0010761 [fibroblast migration]
GO:0010832 [negative regulation of myotube differentiation]
GO:0014909 [smooth muscle cell migration]
GO:0030308 [negative regulation of cell growth]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031012 [extracellular matrix]
GO:0033627 [cell adhesion mediated by integrin]
GO:0035767 [endothelial cell chemotaxis]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044342 [type B pancreatic cell proliferation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046676 [negative regulation of insulin secretion]
GO:0048659 [smooth muscle cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0060326 [cell chemotaxis]
GO:0060392 [negative regulation of SMAD protein import into nucleus]
GO:0060548 [negative regulation of cell death]
GO:0061484 [hematopoietic stem cell homeostasis]
GO:0071603 [endothelial cell-cell adhesion]
GO:0090027 [negative regulation of monocyte chemotaxis]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1904057 [negative regulation of sensory perception of pain]
GO:1990523 [bone regeneration]
Show all
357 aa
39.2 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.