Expression of IL11RA in cancer - Summary - The Human Protein Atlas

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IL11RA

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL11RA
Gene description	Interleukin 11 receptor, alpha
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 3 antibodies. HPA013162 , HPA036652 , CAB032830
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA013162	HPA036652	CAB032830

GENE INFORMATION
Gene name	IL11RA
Synonyms
Description	Interleukin 11 receptor, alpha (HGNC Symbol)
Entrez gene summary	Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	34650702 - 34661892
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137070 (version 83.38)
Entrez gene	3590
UniProt	Q14626 (UniProt - Evidence at protein level)
neXtProt	NX_Q14626
Antibodypedia	IL11RA antibodies

PROTEIN BROWSER

IL11RA-001	IL11RA-002	IL11RA-006	IL11RA-007	IL11RA-010	IL11RA-011	IL11RA-012	IL11RA-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL11RA-001 ENSP00000326500 ENST00000318041	Q14626 [Direct mapping] Interleukin-11 receptor subunit alpha Q5VZ79 [Target identity:100%; Query identity:100%] HCG2011440, isoform CRA_a; cDNA FLJ37370 fis, clone BRAMY2024593, highly similar to Interleukin-11 receptor alpha chain; cDNA FLJ78258, highly similar to Homo sapiens interleukin 11 receptor, alpha (IL11RA), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004871 [signal transducer activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032502 [developmental process] GO:0060322 [head development] Show all	422 aa 45.2 kDa	Yes	1
IL11RA-002 ENSP00000473647 ENST00000602473	Q14626 [Direct mapping] Interleukin-11 receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004871 [signal transducer activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032502 [developmental process] GO:0060322 [head development] Show all	390 aa 41.8 kDa	Yes	1
IL11RA-006 ENSP00000450565 ENST00000555003	Q14626 [Direct mapping] Interleukin-11 receptor subunit alpha Q5VZ79 [Target identity:100%; Query identity:100%] HCG2011440, isoform CRA_a; cDNA FLJ37370 fis, clone BRAMY2024593, highly similar to Interleukin-11 receptor alpha chain; cDNA FLJ78258, highly similar to Homo sapiens interleukin 11 receptor, alpha (IL11RA), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004871 [signal transducer activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007566 [embryo implantation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032502 [developmental process] GO:0060322 [head development] Show all	422 aa 45.2 kDa	Yes	1
IL11RA-007 ENSP00000450640 ENST00000555981	G3V2G0 [Direct mapping] Interleukin-11 receptor subunit alpha Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	270 aa 29.1 kDa	Yes	0
IL11RA-010 ENSP00000451447 ENST00000556531	G3V3V2 [Direct mapping] Interleukin-11 receptor subunit alpha Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	167 aa 17.4 kDa	Yes	0
IL11RA-011 ENSP00000452207 ENST00000553620	G3V571 [Direct mapping] Interleukin-11 receptor subunit alpha Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	152 aa 16.3 kDa	Yes	0
IL11RA-012 ENSP00000394391 ENST00000441545	Q14626 [Direct mapping] Interleukin-11 receptor subunit alpha Q5VZ79 [Target identity:100%; Query identity:100%] HCG2011440, isoform CRA_a; cDNA FLJ37370 fis, clone BRAMY2024593, highly similar to Interleukin-11 receptor alpha chain; cDNA FLJ78258, highly similar to Homo sapiens interleukin 11 receptor, alpha (IL11RA), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004871 [signal transducer activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032502 [developmental process] GO:0060322 [head development] Show all	422 aa 45.2 kDa	Yes	1
IL11RA-015 ENSP00000450543 ENST00000556792	G3V2A5 [Direct mapping] Interleukin-11 receptor subunit alpha Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	139 aa 14.2 kDa	Yes	0

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The Human Protein Atlas

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