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CCL21

GENERAL INFORMATION

Gene name

 CCL21

Gene description

 Chemokine (C-C motif) ligand 21

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Tissue enhanced (small intestine, thyroid gland)
FANTOM5:Tissue enhanced (lymph node, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in subsets of cells in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA051210 , CAB005067
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)

GENE INFORMATION

Gene name

 CCL21 (HGNC Symbol)

Synonyms

 6Ckine, CKb9, ECL, exodus-2, SCYA21, SLC, TCA4

Description

 Chemokine (C-C motif) ligand 21 (HGNC Symbol)

Entrez gene summary

 This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 34709005 - 34710124

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137077 (version 83.38)

Entrez gene

 6366

UniProt

 O00585 (UniProt - Evidence at protein level)

neXtProt

 NX_O00585

Antibodypedia

 CCL21 antibodies

PROTEIN BROWSER
CCL21-001
CCL21-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL21-001
ENSP00000368069
ENST00000378792
Q5VZ73 [Direct mapping]
C-C motif chemokine 21
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0060326 [cell chemotaxis]
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 124 aa
13.6 kDa 		Yes 0
CCL21-002
ENSP00000259607
ENST00000259607
O00585 [Direct mapping]
C-C motif chemokine 21
Q6ICR7 [Target identity:100%; Query identity:100%]
CCL21 protein; Chemokine (C-C motif) ligand 21; Efficient Chemoattractant for Lymphocytes; cDNA, FLJ92167, Homo sapiens chemokine (C-C motif) ligand 21 (CCL21), mRNA
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001768 [establishment of T cell polarity]
GO:0001771 [immunological synapse formation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002407 [dendritic cell chemotaxis]
GO:0002548 [monocyte chemotaxis]
GO:0002606 [positive regulation of dendritic cell antigen processing and presentation]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0010560 [positive regulation of glycoprotein biosynthetic process]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031529 [ruffle organization]
GO:0031732 [CCR7 chemokine receptor binding]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0034695 [response to prostaglandin E]
GO:0035759 [mesangial cell-matrix adhesion]
GO:0042379 [chemokine receptor binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0048020 [CCR chemokine receptor binding]
GO:0048247 [lymphocyte chemotaxis]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0048469 [cell maturation]
GO:0050921 [positive regulation of chemotaxis]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060326 [cell chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090630 [activation of GTPase activity]
GO:0097026 [dendritic cell dendrite assembly]
GO:1903237 [negative regulation of leukocyte tethering or rolling]
GO:2000107 [negative regulation of leukocyte apoptotic process]
GO:2000147 [positive regulation of cell motility]
GO:2000406 [positive regulation of T cell migration]
GO:2000529 [positive regulation of myeloid dendritic cell chemotaxis]
GO:2000548 [negative regulation of dendritic cell dendrite assembly]
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 134 aa
14.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.