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DCTN3

GENERAL INFORMATION

Gene name

 DCTN3

Gene description

 Dynactin 3 (p22)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044905
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044905

GENE INFORMATION

Gene name

 DCTN3 (HGNC Symbol)

Synonyms

 DCTN-22

Description

 Dynactin 3 (p22) (HGNC Symbol)

Entrez gene summary

 This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 34613545 - 34620523

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137100 (version 83.38)

Entrez gene

 11258

UniProt

 O75935 (UniProt - Evidence at protein level)

neXtProt

 NX_O75935

Antibodypedia

 DCTN3 antibodies

PROTEIN BROWSER
DCTN3-003
DCTN3-004
DCTN3-007
DCTN3-008
DCTN3-009
DCTN3-010
DCTN3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCTN3-003
ENSP00000390842
ENST00000421919
X6RCK5 [Direct mapping]
Dynactin subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 151 aa
17.3 kDa 		No 0
DCTN3-004
ENSP00000432915
ENST00000477738
X6RLR1 [Direct mapping]
Dynactin subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 176 aa
20 kDa 		No 0
DCTN3-007
ENSP00000368191
ENST00000378911
A0A0A0MRV8 [Direct mapping]
Dynactin subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 161 aa
18.2 kDa 		No 0
DCTN3-008
ENSP00000259632
ENST00000259632
O75935 [Direct mapping]
Dynactin subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0000910 [cytokinesis]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005869 [dynactin complex]
GO:0005875 [microtubule associated complex]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0007067 [mitotic nuclear division]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0048471 [perinuclear region of cytoplasm]
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 186 aa
21.1 kDa 		No 0
DCTN3-009
ENSP00000343986
ENST00000341694
O75935 [Direct mapping]
Dynactin subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0000910 [cytokinesis]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005869 [dynactin complex]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0048471 [perinuclear region of cytoplasm]
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 176 aa
19.5 kDa 		No 0
DCTN3-010
ENSP00000368193
ENST00000378913
X6RA56 [Direct mapping]
Dynactin subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 142 aa
16.1 kDa 		No 0
DCTN3-201
ENSP00000368196
ENST00000378916
O75935 [Direct mapping]
Dynactin subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0000910 [cytokinesis]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005869 [dynactin complex]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 158 aa
18 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.