Expression of CD72 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CD72

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD72
Gene description	CD72 molecule
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, Karpas-707, U-698)
HPA (normal tissue):	Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective membranous expression in lymphocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA044658 , CAB002505
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044658	CAB002505

GENE INFORMATION
Gene name	CD72 (HGNC Symbol)
Synonyms	CD72b, LYB2
Description	CD72 molecule (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	35609533 - 35646810
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137101 (version 83.38)
Entrez gene	971
UniProt	P21854 (UniProt - Evidence at transcript level)
neXtProt	NX_P21854
Antibodypedia	CD72 antibodies

PROTEIN BROWSER

CD72-001	CD72-005	CD72-009	CD72-201	CD72-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD72-001 ENSP00000379980 ENST00000396757	P21854 [Direct mapping] B-cell differentiation antigen CD72 Q5TLG3 [Target identity:100%; Query identity:100%] CD72 antigen; CD72 antigen, isoform CRA_a; CD72 molecule Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0030246 [carbohydrate binding] Show all	359 aa 40.2 kDa	No	1
CD72-005 ENSP00000367687 ENST00000378430	Q5T4Q7 [Direct mapping] B-cell differentiation antigen CD72 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 12.2 kDa	No	0
CD72-009 ENSP00000367688 ENST00000378431	Q5T4Q8 [Direct mapping] B-cell differentiation antigen CD72 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	119 aa 12.5 kDa	No	1
CD72-201 ENSP00000259633 ENST00000259633	P21854 [Direct mapping] B-cell differentiation antigen CD72 Q5TLG3 [Target identity:100%; Query identity:100%] CD72 antigen; CD72 antigen, isoform CRA_a; CD72 molecule Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0030246 [carbohydrate binding] Show all	359 aa 40.2 kDa	No	1
CD72-202 ENSP00000483742 ENST00000612238	A0A087X0Y7 [Direct mapping] B-cell differentiation antigen CD72 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	359 aa 40.1 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.