Expression of TMEM8B in cancer - Summary - The Human Protein Atlas

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TMEM8B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM8B
Gene description	Transmembrane protein 8B
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA052130
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052130

GENE INFORMATION
Gene name	TMEM8B (HGNC Symbol)
Synonyms	C9orf127, NAG-5, NGX6
Description	Transmembrane protein 8B (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	35814451 - 35854847
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137103 (version 83.38)
Entrez gene	51754
UniProt	A6NDV4 (UniProt - Evidence at protein level)
neXtProt	NX_A6NDV4
Antibodypedia	TMEM8B antibodies

PROTEIN BROWSER

TMEM8B-001	TMEM8B-005	TMEM8B-007	TMEM8B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM8B-001 ENSP00000395810 ENST00000439587	A6NDV4 [Direct mapping] Transmembrane protein 8B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007346 [regulation of mitotic cell cycle] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] Show all	338 aa 36.8 kDa	No	2
TMEM8B-005 ENSP00000367230 ENST00000377991	A6NDV4 [Direct mapping] Transmembrane protein 8B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007346 [regulation of mitotic cell cycle] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] Show all	472 aa 51.9 kDa	No	7
TMEM8B-007 ENSP00000367235 ENST00000377996	A6NDV4 [Direct mapping] Transmembrane protein 8B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007346 [regulation of mitotic cell cycle] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] Show all	338 aa 36.8 kDa	No	2
TMEM8B-201 ENSP00000367227 ENST00000377988	A6NDV4 [Direct mapping] Transmembrane protein 8B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007346 [regulation of mitotic cell cycle] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] Show all	472 aa 51.9 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.