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GRHPR

GENERAL INFORMATION

Gene name

 GRHPR

Gene description

 Glyoxylate reductase/hydroxypyruvate reductase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA022971
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022971

GENE INFORMATION

Gene name

 GRHPR (HGNC Symbol)

Synonyms

 GLXR, PH2

Description

 Glyoxylate reductase/hydroxypyruvate reductase (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p13.2

Chromosome location (bp)

 37422666 - 37436990

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137106 (version 83.38)

Entrez gene

 9380

UniProt

 Q9UBQ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBQ7

Antibodypedia

 GRHPR antibodies

PROTEIN BROWSER
GRHPR-002
GRHPR-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRHPR-002
ENSP00000313432
ENST00000318158
Q9UBQ7 [Direct mapping]
Glyoxylate reductase/hydroxypyruvate reductase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0007588 [excretion]
GO:0008152 [metabolic process]
GO:0008465 [glycerate dehydrogenase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0016618 [hydroxypyruvate reductase activity]
GO:0030267 [glyoxylate reductase (NADP) activity]
GO:0031406 [carboxylic acid binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043648 [dicarboxylic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046487 [glyoxylate metabolic process]
GO:0050661 [NADP binding]
GO:0051259 [protein oligomerization]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070402 [NADPH binding]
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 328 aa
35.7 kDa 		No 0
GRHPR-011
ENSP00000475569
ENST00000607784
U3KQ56 [Direct mapping]
Glyoxylate reductase/hydroxypyruvate reductase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
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 358 aa
38.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.