Expression of ALDH1B1 in cancer - Summary - The Human Protein Atlas

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ALDH1B1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ALDH1B1
Gene description	Aldehyde dehydrogenase 1 family, member B1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA021037
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable) and renal cancer (favourable).
Thyroid cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021037

GENE INFORMATION
Gene name	ALDH1B1 (HGNC Symbol)
Synonyms	ALDH5, ALDHX
Description	Aldehyde dehydrogenase 1 family, member B1 (HGNC Symbol)
Entrez gene summary	This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p13.1
Chromosome location (bp)	38392664 - 38398661
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137124 (version 83.38)
Entrez gene	219
UniProt	P30837 (UniProt - Evidence at protein level)
neXtProt	NX_P30837
Antibodypedia	ALDH1B1 antibodies

PROTEIN BROWSER

ALDH1B1-001	ALDH1B1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH1B1-001 ENSP00000366927 ENST00000377698	P30837 [Direct mapping] Aldehyde dehydrogenase X, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005975 [carbohydrate metabolic process] GO:0006068 [ethanol catabolic process] GO:0006069 [ethanol oxidation] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	517 aa 57.2 kDa	No	0
ALDH1B1-002 ENSP00000489053 ENST00000635162		Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	130 aa 14.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.