Expression of IGFBPL1 in cancer - Summary - The Human Protein Atlas

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IGFBPL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IGFBPL1
Gene description	Insulin-like growth factor binding protein-like 1
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (AF22, NTERA-2, RH-30, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA051354
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051354

GENE INFORMATION
Gene name	IGFBPL1 (HGNC Symbol)
Synonyms	bA113O24.1
Description	Insulin-like growth factor binding protein-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p13.1
Chromosome location (bp)	38408994 - 38424447
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137142 (version 83.38)
Entrez gene	347252
UniProt	Q8WX77 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WX77
Antibodypedia	IGFBPL1 antibodies

PROTEIN BROWSER

IGFBPL1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGFBPL1-001 ENSP00000366923 ENST00000377694	Q8WX77 [Direct mapping] Insulin-like growth factor-binding protein-like 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] Show all	278 aa 29 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.