Expression of CNPY3 in cancer - Summary - The Human Protein Atlas

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CNPY3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNPY3
Gene description	Canopy FGF signaling regulator 3
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA016560
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016560

GENE INFORMATION
Gene name	CNPY3 (HGNC Symbol)
Synonyms	CAG4A, TNRC5
Description	Canopy FGF signaling regulator 3 (HGNC Symbol)
Entrez gene summary	PRAT4A is associated with the immature form of TLR4 (MIM 603030) and regulates its cell surface expression (Wakabayashi et al., 2006 [PubMed 16849487]).[supplied by OMIM, Mar 2008]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	42929192 - 42939287
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137161 (version 83.38)
Entrez gene	10695
UniProt	Q9BT09 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BT09
Antibodypedia	CNPY3 antibodies

PROTEIN BROWSER

CNPY3-001	CNPY3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNPY3-001 ENSP00000361926 ENST00000372836	Q9BT09 [Direct mapping] Protein canopy homolog 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0005102 [receptor binding] GO:0005788 [endoplasmic reticulum lumen] GO:0045087 [innate immune response] Show all	278 aa 30.7 kDa	Yes	0
CNPY3-201 ENSP00000377698 ENST00000394142	A0A0C4DFY8 [Direct mapping] Protein canopy homolog 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 16 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.