Expression of LRRC1 in cancer - Summary - The Human Protein Atlas

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LRRC1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRC1
Gene description	Leucine rich repeat containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in most glandular epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA031603
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031603

GENE INFORMATION
Gene name	LRRC1 (HGNC Symbol)
Synonyms	dJ523E19.1, FLJ10775, FLJ11834, LANO
Description	Leucine rich repeat containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p12.1
Chromosome location (bp)	53794497 - 53924121
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137269 (version 83.38)
Entrez gene	55227
UniProt	Q9BTT6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTT6
Antibodypedia	LRRC1 antibodies

PROTEIN BROWSER

LRRC1-003	LRRC1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC1-003 ENSP00000359925 ENST00000370888	Q9BTT6 [Direct mapping] Leucine-rich repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016020 [membrane] Show all	524 aa 59.2 kDa	No	0
LRRC1-005 ENSP00000359919 ENST00000370882	Q5T0G3 [Direct mapping] Leucine-rich repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	154 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.