Expression of BPHL in cancer - Summary - The Human Protein Atlas

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BPHL

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BPHL
Gene description	Biphenyl hydrolase-like (serine hydrolase)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression, most abundant in renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA036752 , HPA036753
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036752	HPA036753

GENE INFORMATION
Gene name	BPHL (HGNC Symbol)
Synonyms	Bph-rp, MCNAA
Description	Biphenyl hydrolase-like (serine hydrolase) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	3118374 - 3153578
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137274 (version 83.38)
Entrez gene	670
UniProt	Q86WA6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86WA6
Antibodypedia	BPHL antibodies

PROTEIN BROWSER

BPHL-001	BPHL-007	BPHL-010	BPHL-201	BPHL-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BPHL-001 ENSP00000369739 ENST00000380379	Q86WA6 [Direct mapping] Valacyclovir hydrolase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006520 [cellular amino acid metabolic process] GO:0009636 [response to toxic substance] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	291 aa 32.5 kDa	No	0
BPHL-007 ENSP00000390472 ENST00000434640	Q86WA6 [Direct mapping] Valacyclovir hydrolase A0A024QZY0 [Target identity:100%; Query identity:100%] Biphenyl hydrolase-like (Serine hydrolase breast epithelial mucin-associated antigen), isoform CRA_d Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006520 [cellular amino acid metabolic process] GO:0009636 [response to toxic substance] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	274 aa 31.1 kDa	No	0
BPHL-010 ENSP00000395744 ENST00000423798	H7C0M3 [Direct mapping] Valacyclovir hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.2 kDa	No	0
BPHL-201 ENSP00000369726 ENST00000380368	Q49AI2 [Direct mapping] BPHL protein; Biphenyl hydrolase-like (Serine hydrolase breast epithelial mucin-associated antigen), isoform CRA_a; Valacyclovir hydrolase Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	194 aa 21.5 kDa	No	0
BPHL-202 ENSP00000369734 ENST00000380375	Q86WA6 [Direct mapping] Valacyclovir hydrolase A0A024QZY0 [Target identity:100%; Query identity:100%] Biphenyl hydrolase-like (Serine hydrolase breast epithelial mucin-associated antigen), isoform CRA_d Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006520 [cellular amino acid metabolic process] GO:0009636 [response to toxic substance] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	274 aa 31.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.