We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
IER3
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

IER3

Gene description

Immediate early response 3

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (A-431, EFO-21, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (appendix)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA043847
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA043847

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells displayed moderate to strong cytoplasmic staining. Several cases of gliomas, cervical, skin, urothelial and renal cancers were weakly stained or negative.

GENE INFORMATION

Gene name

IER3 (HGNC Symbol)

Synonyms

DIF-2, IEX-1, IEX-1L, PRG1

Description

Immediate early response 3 (HGNC Symbol)

Entrez gene summary

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

30743199 - 30744554

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137331 (version 83.38)

Entrez gene

8870

UniProt

P46695 (UniProt - Evidence at protein level)

neXtProt

NX_P46695

Antibodypedia

IER3 antibodies

PROTEIN BROWSER

IER3-001
IER3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IER3-001
ENSP00000259874
ENST00000259874
P46695 [Direct mapping]
Radiation-inducible immediate-early gene IEX-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001562 [response to protozoan]
GO:0003085 [negative regulation of systemic arterial blood pressure]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006282 [regulation of DNA repair]
GO:0006915 [apoptotic process]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009653 [anatomical structure morphogenesis]
GO:0016021 [integral component of membrane]
GO:0043066 [negative regulation of apoptotic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045820 [negative regulation of glycolytic process]
GO:0046822 [regulation of nucleocytoplasmic transport]
GO:0050728 [negative regulation of inflammatory response]
GO:1901029 [negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
156 aa
16.9 kDa
No 1
IER3-002
ENSP00000365557
ENST00000376377
Q5ST79 [Direct mapping]
Immediate early response 3, isoform CRA_b; Radiation-inducible immediate-early gene IEX-1
Show all
Predicted intracellular proteins
Show all
GO:0043066 [negative regulation of apoptotic process]
Show all
138 aa
14.6 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.