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ATAT1

GENERAL INFORMATION

Gene name

 ATAT1

Gene description

 Alpha tubulin acetyltransferase 1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression, abundant in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA046816 , HPA050999
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and urothelial cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046816
HPA050999

GENE INFORMATION

Gene name

 ATAT1 (HGNC Symbol)

Synonyms

 C6orf134, Em:AB023049.7, FLJ13158, MEC17

Description

 Alpha tubulin acetyltransferase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 30626842 - 30646823

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137343 (version 83.38)

Entrez gene

 79969

UniProt

 Q5SQI0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5SQI0

Antibodypedia

 ATAT1 antibodies

PROTEIN BROWSER
ATAT1-001
ATAT1-002
ATAT1-003
ATAT1-004
ATAT1-005
ATAT1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATAT1-001
ENSP00000324222
ENST00000318999
Q5SQI0 [Direct mapping]
Alpha-tubulin N-acetyltransferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006996 [organelle organization]
GO:0019799 [tubulin N-acetyltransferase activity]
GO:0030424 [axon]
GO:0048666 [neuron development]
GO:0050662 [coenzyme binding]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071929 [alpha-tubulin acetylation]
GO:0072686 [mitotic spindle]
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 300 aa
34 kDa 		No 0
ATAT1-002
ENSP00000365668
ENST00000376485
Q5SQI0 [Direct mapping]
Alpha-tubulin N-acetyltransferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006996 [organelle organization]
GO:0019799 [tubulin N-acetyltransferase activity]
GO:0030424 [axon]
GO:0048666 [neuron development]
GO:0050662 [coenzyme binding]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071929 [alpha-tubulin acetylation]
GO:0072686 [mitotic spindle]
Show all
 421 aa
46.8 kDa 		No 0
ATAT1-003
ENSP00000365666
ENST00000376483
Q5SQI0 [Direct mapping]
Alpha-tubulin N-acetyltransferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006996 [organelle organization]
GO:0019799 [tubulin N-acetyltransferase activity]
GO:0030424 [axon]
GO:0048666 [neuron development]
GO:0050662 [coenzyme binding]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071929 [alpha-tubulin acetylation]
GO:0072686 [mitotic spindle]
Show all
 323 aa
36.3 kDa 		No 0
ATAT1-004
ENSP00000327832
ENST00000330083
Q5SQI0 [Direct mapping]
Alpha-tubulin N-acetyltransferase 1
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Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006996 [organelle organization]
GO:0007283 [spermatogenesis]
GO:0019799 [tubulin N-acetyltransferase activity]
GO:0021542 [dentate gyrus development]
GO:0030424 [axon]
GO:0045598 [regulation of fat cell differentiation]
GO:0048666 [neuron development]
GO:0050662 [coenzyme binding]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071929 [alpha-tubulin acetylation]
GO:0072686 [mitotic spindle]
GO:0097427 [microtubule bundle]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
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 409 aa
45.6 kDa 		Yes 0
ATAT1-005
ENSP00000324459
ENST00000319027
Q5SQI0 [Direct mapping]
Alpha-tubulin N-acetyltransferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006996 [organelle organization]
GO:0019799 [tubulin N-acetyltransferase activity]
GO:0030424 [axon]
GO:0048666 [neuron development]
GO:0050662 [coenzyme binding]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071929 [alpha-tubulin acetylation]
GO:0072686 [mitotic spindle]
Show all
 310 aa
35.1 kDa 		No 0
ATAT1-006
ENSP00000332374
ENST00000329992
Q5SQI0 [Direct mapping]
Alpha-tubulin N-acetyltransferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006996 [organelle organization]
GO:0019799 [tubulin N-acetyltransferase activity]
GO:0030424 [axon]
GO:0048666 [neuron development]
GO:0050662 [coenzyme binding]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071929 [alpha-tubulin acetylation]
GO:0072686 [mitotic spindle]
Show all
 333 aa
37.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.