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TPMT

GENERAL INFORMATION

Gene name

 TPMT

Gene description

 Thiopurine S-methyltransferase

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA019851
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), renal cancer (favourable) and ovarian cancer (favourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019851

GENE INFORMATION

Gene name

 TPMT

Synonyms

Description

 Thiopurine S-methyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

Chromosome

 6

Cytoband

 p22.3

Chromosome location (bp)

 18128311 - 18155074

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137364 (version 83.38)

Entrez gene

 7172

UniProt

 P51580 (UniProt - Evidence at protein level)

neXtProt

 NX_P51580

Antibodypedia

 TPMT antibodies

PROTEIN BROWSER
TPMT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPMT-001
ENSP00000312304
ENST00000309983
P51580 [Direct mapping]
Thiopurine S-methyltransferase
A0A024QZW0 [Target identity:100%; Query identity:100%]
Thiopurine S-methyltransferase, isoform CRA_d
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008119 [thiopurine S-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0032259 [methylation]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 245 aa
28.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.