Expression of VARS2 in cancer - Summary - The Human Protein Atlas

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VARS2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	VARS2
Gene description	Valyl-tRNA synthetase 2, mitochondrial
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA070267
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA070267

GENE INFORMATION
Gene name	VARS2 (HGNC Symbol)
Synonyms	DKFZP434L1435, G7a, KIAA1885, VARS2L, VARSL
Description	Valyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	30908242 - 30926459
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137411 (version 83.38)
Entrez gene	57176
UniProt	Q5ST30 (UniProt - Evidence at protein level)
neXtProt	NX_Q5ST30
Antibodypedia	VARS2 antibodies

PROTEIN BROWSER

VARS2-001	VARS2-006	VARS2-008	VARS2-012	VARS2-013	VARS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VARS2-001 ENSP00000316092 ENST00000321897	Q5ST30 [Direct mapping] Valine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0002161 [aminoacyl-tRNA editing activity] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004832 [valine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006438 [valyl-tRNA aminoacylation] GO:0006450 [regulation of translational fidelity] GO:0010467 [gene expression] Show all	1063 aa 118.5 kDa	No	0
VARS2-006 ENSP00000403749 ENST00000428017	B7ZCJ6 [Direct mapping] Valine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004832 [valine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006438 [valyl-tRNA aminoacylation] Show all	326 aa 36.9 kDa	No	0
VARS2-008 ENSP00000416390 ENST00000421263	A2ABL6 [Direct mapping] Valine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004832 [valine-tRNA ligase activity] GO:0006438 [valyl-tRNA aminoacylation] Show all	115 aa 13.1 kDa	No	0
VARS2-012 ENSP00000485818 ENST00000625423	Q5ST30 [Direct mapping] Valine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0002161 [aminoacyl-tRNA editing activity] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004832 [valine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006438 [valyl-tRNA aminoacylation] GO:0006450 [regulation of translational fidelity] GO:0010467 [gene expression] Show all	923 aa 102.4 kDa	No	0
VARS2-013 ENSP00000441000 ENST00000541562	Q5ST30 [Direct mapping] Valine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0002161 [aminoacyl-tRNA editing activity] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004832 [valine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006438 [valyl-tRNA aminoacylation] GO:0006450 [regulation of translational fidelity] GO:0010467 [gene expression] Show all	1093 aa 121.5 kDa	No	0
VARS2-201 ENSP00000438200 ENST00000542001	A0A0A0MTG1 [Direct mapping] Valine--tRNA ligase, mitochondrial Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0002161 [aminoacyl-tRNA editing activity] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004832 [valine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006438 [valyl-tRNA aminoacylation] GO:0006450 [regulation of translational fidelity] Show all	1061 aa 118.4 kDa	No	0

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