Cell atlas - NUMA1 - The Human Protein Atlas

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NUMA1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NUMA1
Gene description	Nuclear mitotic apparatus protein 1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	23
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA019841 , HPA029912
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019841	A-431	Nucleoplasm
	HPA019841	A-431	Cytosol
	HPA019841	U-2 OS	Nucleoplasm
	HPA019841	U-251 MG	Nucleoplasm
	HPA029912	A-431	Nucleoplasm
	HPA029912	U-2 OS	Nucleoplasm
	HPA029912	U-251 MG	Nucleoplasm

siRNA VALIDATION

Antibody

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

71%

p-value

< 0.01

Antibody

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 2

RFI

39%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail 10x	Thumbnail 40x	Antibody	Sample	Cell line
		HPA019841	siRNA 1	U-2 OS
		HPA019841	scrambled	U-2 OS
		HPA029912	siRNA 2	U-2 OS
		HPA029912	scrambled	U-2 OS

GENE INFORMATION
Gene name	NUMA1
Synonyms
Description	Nuclear mitotic apparatus protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	72002864 - 72080693
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137497 (version 83.38)
Entrez gene	4926
UniProt	Q14980 (UniProt - Evidence at protein level)
neXtProt	NX_Q14980
Antibodypedia	NUMA1 antibodies

PROTEIN BROWSER

NUMA1-001	NUMA1-002	NUMA1-005	NUMA1-006	NUMA1-009	NUMA1-012	NUMA1-014	NUMA1-015	NUMA1-017	NUMA1-018	NUMA1-019	NUMA1-020	NUMA1-021	NUMA1-022	NUMA1-023	NUMA1-024	NUMA1-025	NUMA1-026	NUMA1-027	NUMA1-028	NUMA1-201	NUMA1-202	NUMA1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUMA1-001 ENSP00000377298 ENST00000393695	Q14980 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000132 [establishment of mitotic spindle orientation] GO:0000139 [Golgi membrane] GO:0000278 [mitotic cell cycle] GO:0000922 [spindle pole] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0005938 [cell cortex] GO:0006997 [nucleus organization] GO:0007067 [mitotic nuclear division] GO:0008017 [microtubule binding] GO:0016363 [nuclear matrix] GO:0030425 [dendrite] GO:0043025 [neuronal cell body] GO:0045177 [apical part of cell] GO:0051301 [cell division] GO:0051321 [meiotic cell cycle] GO:0060487 [lung epithelial cell differentiation] GO:0070062 [extracellular exosome] GO:0097431 [mitotic spindle pole] Show all	2115 aa 238.3 kDa	No	0
NUMA1-002 ENSP00000351851 ENST00000358965	Q14980 [Direct mapping] Nuclear mitotic apparatus protein 1 A0A024R5M9 [Target identity:100%; Query identity:100%] Nuclear mitotic apparatus protein 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000139 [Golgi membrane] GO:0000278 [mitotic cell cycle] GO:0000922 [spindle pole] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0005938 [cell cortex] GO:0006997 [nucleus organization] GO:0007067 [mitotic nuclear division] GO:0016363 [nuclear matrix] GO:0051301 [cell division] GO:0070062 [extracellular exosome] GO:0097431 [mitotic spindle pole] Show all	2101 aa 236.5 kDa	No	0
NUMA1-005 ENSP00000442936 ENST00000537217	F5H6Y5 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	691 aa 78.3 kDa	No	0
NUMA1-006 ENSP00000260051 ENST00000351960	Q14980 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000139 [Golgi membrane] GO:0000278 [mitotic cell cycle] GO:0000922 [spindle pole] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0005938 [cell cortex] GO:0006997 [nucleus organization] GO:0007067 [mitotic nuclear division] GO:0016363 [nuclear matrix] GO:0051301 [cell division] GO:0070062 [extracellular exosome] GO:0097431 [mitotic spindle pole] Show all	979 aa 109.3 kDa	No	0
NUMA1-009 ENSP00000444880 ENST00000542977	F5H4J1 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	852 aa 97.1 kDa	No	0
NUMA1-012 ENSP00000440954 ENST00000541584	H0YFY6 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	964 aa 107.3 kDa	No	0
NUMA1-014 ENSP00000441598 ENST00000541641	F5GWK2 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		72 aa 8.1 kDa	No	0
NUMA1-015 ENSP00000439759 ENST00000543937	F5H0Z7 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	201 aa 22.5 kDa	No	0
NUMA1-017 ENSP00000357955 ENST00000368959	F8W6T3 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	91 aa 10.1 kDa	No	0
NUMA1-018 ENSP00000442331 ENST00000546131	F5H7R5 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.2 kDa	No	0
NUMA1-019 ENSP00000441674 ENST00000535111	F5GWA2 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.8 kDa	No	0
NUMA1-020 ENSP00000438331 ENST00000541719	F5H068 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	83 aa 9.3 kDa	No	0
NUMA1-021 ENSP00000438318 ENST00000366394	F5H073 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	75 aa 8.5 kDa	No	0
NUMA1-022 ENSP00000444831 ENST00000535838	F5H4Y4 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.5 kDa	No	0
NUMA1-023 ENSP00000439576 ENST00000535087	F5H1L0 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	109 aa 12.2 kDa	No	0
NUMA1-024 ENSP00000438821 ENST00000543009	F5H3L6 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	174 aa 19.6 kDa	No	0
NUMA1-025 ENSP00000438589 ENST00000537930	F5H2F3 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	159 aa 18 kDa	No	0
NUMA1-026 ENSP00000442761 ENST00000544238	F5H763 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	220 aa 24.7 kDa	No	0
NUMA1-027 ENSP00000444175 ENST00000535947	F5GZW1 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	146 aa 16.6 kDa	No	0
NUMA1-028 ENSP00000439092 ENST00000544129	F5H2F3 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	159 aa 18 kDa	No	0
NUMA1-201 ENSP00000480172 ENST00000613205	Q14980 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000139 [Golgi membrane] GO:0000278 [mitotic cell cycle] GO:0000922 [spindle pole] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0005938 [cell cortex] GO:0006997 [nucleus organization] GO:0007067 [mitotic nuclear division] GO:0016363 [nuclear matrix] GO:0051301 [cell division] GO:0070062 [extracellular exosome] GO:0097431 [mitotic spindle pole] Show all	979 aa 109.3 kDa	No	0
NUMA1-202 ENSP00000481541 ENST00000616538	A0A087WY61 [Direct mapping] Nuclear mitotic apparatus protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] Show all	2099 aa 236.2 kDa	No	0
NUMA1-203 ENSP00000478624 ENST00000620566	Q14980 [Direct mapping] Nuclear mitotic apparatus protein 1 A0A024R5M9 [Target identity:100%; Query identity:100%] Nuclear mitotic apparatus protein 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000139 [Golgi membrane] GO:0000278 [mitotic cell cycle] GO:0000922 [spindle pole] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0005938 [cell cortex] GO:0006997 [nucleus organization] GO:0007067 [mitotic nuclear division] GO:0016363 [nuclear matrix] GO:0051301 [cell division] GO:0070062 [extracellular exosome] GO:0097431 [mitotic spindle pole] Show all	2101 aa 236.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.