Expression of LRRC32 in cancer - Summary - The Human Protein Atlas

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LRRC32

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	LRRC32
Gene description	Leucine rich repeat containing 32
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (ASC TERT1, HUVEC TERT2, U-2197)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	LRRC32 (HGNC Symbol)
Synonyms	D11S833E, GARP
Description	Leucine rich repeat containing 32 (HGNC Symbol)
Entrez gene summary	This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.5
Chromosome location (bp)	76657524 - 76670747
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137507 (version 83.38)
Entrez gene	2615
UniProt	Q14392 (UniProt - Evidence at protein level)
neXtProt	NX_Q14392
Antibodypedia	LRRC32 antibodies

PROTEIN BROWSER

LRRC32-001	LRRC32-002	LRRC32-004	LRRC32-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC32-001 ENSP00000260061 ENST00000260061	Q14392 [Direct mapping] Leucine-rich repeat-containing protein 32 A0A024R5J7 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 32, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] Show all	662 aa 72 kDa	Yes	1
LRRC32-002 ENSP00000413331 ENST00000421973	C9JYU3 [Direct mapping] Leucine-rich repeat-containing protein 32 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	186 aa 20.2 kDa	Yes	0
LRRC32-004 ENSP00000385766 ENST00000404995	Q14392 [Direct mapping] Leucine-rich repeat-containing protein 32 A0A024R5J7 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 32, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] Show all	662 aa 72 kDa	Yes	1
LRRC32-201 ENSP00000384126 ENST00000407242	Q14392 [Direct mapping] Leucine-rich repeat-containing protein 32 A0A024R5J7 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 32, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] Show all	662 aa 72 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.