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MRPL15

GENERAL INFORMATION

Gene name

 MRPL15

Gene description

 Mitochondrial ribosomal protein L15

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression often with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044425
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044425

GENE INFORMATION

Gene name

 MRPL15 (HGNC Symbol)

Synonyms

 HSPC145, L15mt, MRP-L15, MRP-L7, RPML7

Description

 Mitochondrial ribosomal protein L15 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q11.23

Chromosome location (bp)

 54135210 - 54147901

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137547 (version 83.38)

Entrez gene

 29088

UniProt

 Q9P015 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P015

Antibodypedia

 MRPL15 antibodies

PROTEIN BROWSER
MRPL15-001
MRPL15-002
MRPL15-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL15-001
ENSP00000260102
ENST00000260102
Q9P015 [Direct mapping]
39S ribosomal protein L15, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 296 aa
33.4 kDa 		No 0
MRPL15-002
ENSP00000429252
ENST00000522521
E5RIZ4 [Direct mapping]
39S ribosomal protein L15, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
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 237 aa
27.2 kDa 		No 0
MRPL15-003
ENSP00000428581
ENST00000519831
E5RHF4 [Direct mapping]
39S ribosomal protein L15, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
Show all
 198 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.