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GGH

GENERAL INFORMATION

Gene name

 GGH

Gene description

 Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA025226 , CAB019296
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GGH

Synonyms

Description

 Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) (HGNC Symbol)

Entrez gene summary

 This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q12.3

Chromosome location (bp)

 63015079 - 63039171

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137563 (version 83.38)

Entrez gene

 8836

UniProt

 Q92820 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92820

Antibodypedia

 GGH antibodies

PROTEIN BROWSER
GGH-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GGH-001
ENSP00000260118
ENST00000260118
Q92820 [Direct mapping]
Gamma-glutamyl hydrolase
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005764 [lysosome]
GO:0005773 [vacuole]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006541 [glutamine metabolic process]
GO:0008238 [exopeptidase activity]
GO:0008242 [omega peptidase activity]
GO:0010043 [response to zinc ion]
GO:0016787 [hydrolase activity]
GO:0032868 [response to insulin]
GO:0034722 [gamma-glutamyl-peptidase activity]
GO:0042470 [melanosome]
GO:0042493 [response to drug]
GO:0045471 [response to ethanol]
GO:0046900 [tetrahydrofolylpolyglutamate metabolic process]
GO:0070062 [extracellular exosome]
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 318 aa
36 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.