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SDCBP

GENERAL INFORMATION

Gene name

 SDCBP

Gene description

 Syndecan binding protein (syntenin)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, most abundant in melanocytes, lymphoid germinal center and peripheral nerve.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA023840 , CAB012245
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA023840
CAB012245

GENE INFORMATION

Gene name

 SDCBP (HGNC Symbol)

Synonyms

 SYCL

Description

 Syndecan binding protein (syntenin) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q12.1

Chromosome location (bp)

 58552924 - 58582860

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137575 (version 83.38)

Entrez gene

 6386

UniProt

 O00560 (UniProt - Evidence at protein level)

neXtProt

 NX_O00560

Antibodypedia

 SDCBP antibodies

PROTEIN BROWSER
SDCBP-001
SDCBP-002
SDCBP-003
SDCBP-004
SDCBP-005
SDCBP-006
SDCBP-012
SDCBP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SDCBP-001
ENSP00000260130
ENST00000260130
O00560 [Direct mapping]
Syntenin-1
A0A024R7Z5 [Target identity:100%; Query identity:100%]
Syndecan binding protein (Syntenin), isoform CRA_c
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   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0005109 [frizzled binding]
GO:0005137 [interleukin-5 receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005895 [interleukin-5 receptor complex]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0006612 [protein targeting to membrane]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008093 [cytoskeletal adaptor activity]
GO:0016020 [membrane]
GO:0019838 [growth factor binding]
GO:0030036 [actin cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
GO:0042327 [positive regulation of phosphorylation]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045545 [syndecan binding]
GO:0046330 [positive regulation of JNK cascade]
GO:0046875 [ephrin receptor binding]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903553 [positive regulation of extracellular exosome assembly]
GO:1903561 [extracellular vesicle]
Show all
 298 aa
32.4 kDa 		No 0
SDCBP-002
ENSP00000411771
ENST00000413219
O00560 [Direct mapping]
Syntenin-1
A0A024R7Z5 [Target identity:100%; Query identity:100%]
Syndecan binding protein (Syntenin), isoform CRA_c
Show all
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005109 [frizzled binding]
GO:0005137 [interleukin-5 receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005895 [interleukin-5 receptor complex]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0006612 [protein targeting to membrane]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008093 [cytoskeletal adaptor activity]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
GO:0042327 [positive regulation of phosphorylation]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0045545 [syndecan binding]
GO:0046330 [positive regulation of JNK cascade]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903553 [positive regulation of extracellular exosome assembly]
GO:1903561 [extracellular vesicle]
Show all
 298 aa
32.4 kDa 		No 0
SDCBP-003
ENSP00000409288
ENST00000447182
O00560 [Direct mapping]
Syntenin-1
Show all
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005109 [frizzled binding]
GO:0005137 [interleukin-5 receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005895 [interleukin-5 receptor complex]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0006612 [protein targeting to membrane]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008093 [cytoskeletal adaptor activity]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
GO:0042327 [positive regulation of phosphorylation]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0045545 [syndecan binding]
GO:0046330 [positive regulation of JNK cascade]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903553 [positive regulation of extracellular exosome assembly]
GO:1903561 [extracellular vesicle]
Show all
 297 aa
32.3 kDa 		No 0
SDCBP-004
ENSP00000395351
ENST00000424270
O00560 [Direct mapping]
Syntenin-1
Show all
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005109 [frizzled binding]
GO:0005137 [interleukin-5 receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005895 [interleukin-5 receptor complex]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0006612 [protein targeting to membrane]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008093 [cytoskeletal adaptor activity]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
GO:0042327 [positive regulation of phosphorylation]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0045545 [syndecan binding]
GO:0046330 [positive regulation of JNK cascade]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903553 [positive regulation of extracellular exosome assembly]
GO:1903561 [extracellular vesicle]
Show all
 292 aa
31.8 kDa 		No 0
SDCBP-005
ENSP00000428184
ENST00000523483
G5EA09 [Direct mapping]
Syndecan binding protein (Syntenin), isoform CRA_a; Syntenin-1
Show all
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
Show all
 318 aa
34.8 kDa 		No 0
SDCBP-006
ENSP00000430730
ENST00000520168
B4DHN5 [Direct mapping]
Syntenin-1; cDNA FLJ55055, moderately similar to Syntenin-1
Show all
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
Show all
 239 aa
26 kDa 		No 0
SDCBP-012
ENSP00000397820
ENST00000447267
E9PBU7 [Direct mapping]
Syntenin-1
Show all
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
Show all
 244 aa
26.5 kDa 		No 0
SDCBP-201
ENSP00000487245
ENST00000630925
G5EA09 [Direct mapping]
Syndecan binding protein (Syntenin), isoform CRA_a; Syntenin-1
Show all
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
Show all
 318 aa
34.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.