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NEK1

GENERAL INFORMATION

Gene name

 NEK1

Gene description

 NIMA-related kinase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA020873 , HPA040413
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020873
HPA040413

GENE INFORMATION

Gene name

 NEK1 (HGNC Symbol)

Synonyms

 KIAA1901, NY-REN-55

Description

 NIMA-related kinase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 4

Cytoband

 q33

Chromosome location (bp)

 169393275 - 169612629

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137601 (version 83.38)

Entrez gene

 4750

UniProt

 Q96PY6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PY6

Antibodypedia

 NEK1 antibodies

PROTEIN BROWSER
NEK1-001
NEK1-002
NEK1-003
NEK1-004
NEK1-005
NEK1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEK1-001
ENSP00000408020
ENST00000439128
Q96PY6 [Direct mapping]
Serine/threonine-protein kinase Nek1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0000242 [pericentriolar material]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0016301 [kinase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0042384 [cilium assembly]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
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 1258 aa
142.8 kDa 		No 0
NEK1-002
ENSP00000427653
ENST00000510533
Q96PY6 [Direct mapping]
Serine/threonine-protein kinase Nek1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0000242 [pericentriolar material]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0016301 [kinase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0042384 [cilium assembly]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 1214 aa
138.1 kDa 		No 0
NEK1-003
ENSP00000423332
ENST00000511633
Q96PY6 [Direct mapping]
Serine/threonine-protein kinase Nek1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0000242 [pericentriolar material]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0016301 [kinase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0042384 [cilium assembly]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 1242 aa
141.1 kDa 		No 0
NEK1-004
ENSP00000424757
ENST00000507142
Q96PY6 [Direct mapping]
Serine/threonine-protein kinase Nek1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0000242 [pericentriolar material]
GO:0001822 [kidney development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007067 [mitotic nuclear division]
GO:0007283 [spermatogenesis]
GO:0010212 [response to ionizing radiation]
GO:0016301 [kinase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0035264 [multicellular organism growth]
GO:0042384 [cilium assembly]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 1286 aa
145.8 kDa 		No 0
NEK1-005
ENSP00000424938
ENST00000512193
Q96PY6 [Direct mapping]
Serine/threonine-protein kinase Nek1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0000242 [pericentriolar material]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0016301 [kinase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0042384 [cilium assembly]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 1189 aa
135.3 kDa 		No 0
NEK1-008
ENSP00000421525
ENST00000505119
H0Y8M6 [Direct mapping]
Serine/threonine-protein kinase Nek1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005622 [intracellular]
Show all
 123 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.