Expression of NXPE4 in cancer - Summary - The Human Protein Atlas

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NXPE4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NXPE4
Gene description	Neurexophilin and PC-esterase domain family, member 4
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (colorectal cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (colon, rectum, salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in rectum, colon and salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA042801
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042801

GENE INFORMATION
Gene name	NXPE4 (HGNC Symbol)
Synonyms	C11orf33, FAM55D, FLJ20127
Description	Neurexophilin and PC-esterase domain family, member 4 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q23.2
Chromosome location (bp)	114570591 - 114595762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137634 (version 83.38)
Entrez gene	54827
UniProt	Q6UWF7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6UWF7
Antibodypedia	NXPE4 antibodies

PROTEIN BROWSER

NXPE4-001	NXPE4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NXPE4-001 ENSP00000364627 ENST00000375478	Q6UWF7 [Direct mapping] NXPE family member 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0070062 [extracellular exosome] Show all	544 aa 62.3 kDa	Yes	0
NXPE4-002 ENSP00000401503 ENST00000424261	Q6UWF7 [Direct mapping] NXPE family member 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0070062 [extracellular exosome] Show all	260 aa 30.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.