Tissue expression of TRPC6 - Summary - The Human Protein Atlas

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TRPC6

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TRPC6
Gene description	Transient receptor potential cation channel, subfamily C, member 6
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta)
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA045098
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

N/A

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION
Gene name	TRPC6 (HGNC Symbol)
Synonyms	FSGS2, TRP6
Description	Transient receptor potential cation channel, subfamily C, member 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
Chromosome	11
Cytoband	q22.1
Chromosome location (bp)	101451564 - 101872562
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137672 (version 83.38)
Entrez gene	7225
UniProt	Q9Y210 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y210
Antibodypedia	TRPC6 antibodies

PROTEIN BROWSER

TRPC6-001	TRPC6-002	TRPC6-003	TRPC6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPC6-001 ENSP00000340913 ENST00000344327	Q9Y210 [Direct mapping] Short transient receptor potential channel 6 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005261 [cation channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006828 [manganese ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0007568 [aging] GO:0007596 [blood coagulation] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0030182 [neuron differentiation] GO:0030276 [clathrin binding] GO:0032414 [positive regulation of ion transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0036057 [slit diaphragm] GO:0042805 [actinin binding] GO:0045666 [positive regulation of neuron differentiation] GO:0050774 [negative regulation of dendrite morphogenesis] GO:0051117 [ATPase binding] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051928 [positive regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0070301 [cellular response to hydrogen peroxide] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] GO:0071456 [cellular response to hypoxia] Show all	931 aa 106.3 kDa	No	8
TRPC6-002 ENSP00000343672 ENST00000348423	Q9Y210 [Direct mapping] Short transient receptor potential channel 6 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0030168 [platelet activation] GO:0032414 [positive regulation of ion transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051928 [positive regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	815 aa 93.2 kDa	No	7
TRPC6-003 ENSP00000353687 ENST00000360497	Q9Y210 [Direct mapping] Short transient receptor potential channel 6 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0030168 [platelet activation] GO:0032414 [positive regulation of ion transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051928 [positive regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	876 aa 100.1 kDa	No	7
TRPC6-004 ENSP00000435574 ENST00000532133	E9PJN4 [Direct mapping] Short transient receptor potential channel 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006828 [manganese ion transport] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	853 aa 97.3 kDa	No	7

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