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MMP20

GENERAL INFORMATION

Gene name

 MMP20

Gene description

 Matrix metallopeptidase 20

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (breast, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MMP20

Synonyms

Description

 Matrix metallopeptidase 20 (HGNC Symbol)

Entrez gene summary

 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q22.2

Chromosome location (bp)

 102576835 - 102625332

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137674 (version 83.38)

Entrez gene

 9313

UniProt

 O60882 (UniProt - Evidence at protein level)

neXtProt

 NX_O60882

Antibodypedia

 MMP20 antibodies

PROTEIN BROWSER
MMP20-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP20-001
ENSP00000260228
ENST00000260228
O60882 [Direct mapping]
Matrix metalloproteinase-20
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Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
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GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030163 [protein catabolic process]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0070173 [regulation of enamel mineralization]
GO:0097186 [amelogenesis]
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 483 aa
54.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.