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MMP27

GENERAL INFORMATION

Gene name

 MMP27

Gene description

 Matrix metallopeptidase 27

Protein class

 Enzymes
FDA approved drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (breast, skin)
GTEx:Group enriched (adipose tissue, breast, salivary gland, skin)
FANTOM5:Tissue enhanced (epididymis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA069097
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (breast, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, breast, salivary gland, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (epididymis)

GENE INFORMATION

Gene name

 MMP27

Synonyms

Description

 Matrix metallopeptidase 27 (HGNC Symbol)

Entrez gene summary

 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q22.2

Chromosome location (bp)

 102691487 - 102705806

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137675 (version 83.38)

Entrez gene

 64066

UniProt

 Q9H306 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H306

Antibodypedia

 MMP27 antibodies

PROTEIN BROWSER
MMP27-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP27-001
ENSP00000260229
ENST00000260229
Q9H306 [Direct mapping]
Matrix metalloproteinase-27
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Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
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GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
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 513 aa
59 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.