Expression of TRIM29 in cancer - Summary

GENERAL INFORMATION
Gene name	TRIM29
Gene description	Tripartite motif containing 29
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Group enriched (HaCaT, hTCEpi, RT4, SiHa)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in epithelium in several tissues, strongest in squamous epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA020053
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), pancreatic cancer (unfavourable) and stomach cancer (favourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA020053

GENE INFORMATION
Gene name	TRIM29 (HGNC Symbol)
Synonyms	ATDC, FLJ36085
Description	Tripartite motif containing 29 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	120111275 - 120185529
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137699 (version 83.38)
Entrez gene	23650
UniProt	Q14134 (UniProt - Evidence at protein level)
neXtProt	NX_Q14134
Antibodypedia	TRIM29 antibodies

PROTEIN BROWSER

TRIM29-001	TRIM29-005	TRIM29-006	TRIM29-010	TRIM29-011	TRIM29-012	TRIM29-013	TRIM29-018	TRIM29-020	TRIM29-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIM29-001 ENSP00000343129 ENST00000341846	Q14134 [Direct mapping] Tripartite motif-containing protein 29 A0A024R3J1 [Target identity:100%; Query identity:100%] Tripartite motif-containing 29, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0045111 [intermediate filament cytoskeleton] GO:1900181 [negative regulation of protein localization to nucleus] Show all	588 aa 65.8 kDa	No	0
TRIM29-005 ENSP00000436015 ENST00000529044	E9PRL4 [Direct mapping] Tripartite motif-containing protein 29 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		327 aa 37.4 kDa	No	0
TRIM29-006 ENSP00000435696 ENST00000528870	E9PIQ2 [Direct mapping] Tripartite motif-containing protein 29 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 13.6 kDa	No	0
TRIM29-010 ENSP00000433084 ENST00000529040	E9PM74 [Direct mapping] Tripartite motif-containing protein 29 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		38 aa 3.7 kDa	No	0
TRIM29-011 ENSP00000436567 ENST00000532833	E9PI31 [Direct mapping] Tripartite motif-containing protein 29 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9 kDa	No	0
TRIM29-012 ENSP00000433324 ENST00000529495	E9PLI4 [Direct mapping] Tripartite motif-containing protein 29 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 9.8 kDa	No	0
TRIM29-013 ENSP00000435600 ENST00000529011	E9PJ94 [Direct mapping] Tripartite motif-containing protein 29 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 10 kDa	No	0
TRIM29-018 ENSP00000436279 ENST00000526881	E9PPX1 [Direct mapping] Tripartite motif-containing protein 29 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.6 kDa	No	0
TRIM29-020 ENSP00000437078 ENST00000533302	H0YF27 [Direct mapping] Tripartite motif-containing protein 29 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 18.7 kDa	No	0
TRIM29-201 ENSP00000485773 ENST00000627238	E9PJD4 [Direct mapping] Tripartite motif-containing protein 29 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 17.3 kDa	No	0