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RDX

GENERAL INFORMATION

Gene name

 RDX

Gene description

 Radixin

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression at variable levels in several different cell types. Most abundant in adrenal gland and renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA000263 , HPA000763 , CAB037312
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000263
HPA000763
CAB037312

GENE INFORMATION

Gene name

 RDX (HGNC Symbol)

Synonyms

 DFNB24

Description

 Radixin (HGNC Symbol)

Entrez gene summary

 Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

 11

Cytoband

 q22.3

Chromosome location (bp)

 110174880 - 110296722

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137710 (version 83.38)

Entrez gene

 5962

UniProt

 P35241 (UniProt - Evidence at protein level)

neXtProt

 NX_P35241

Antibodypedia

 RDX antibodies

PROTEIN BROWSER
RDX-001
RDX-002
RDX-003
RDX-004
RDX-006
RDX-010
RDX-012
RDX-014
RDX-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RDX-001
ENSP00000342830
ENST00000343115
P35241 [Direct mapping]
Radixin
B0YJ88 [Target identity:100%; Query identity:100%]
Radixin; Radixin, isoform CRA_b; cDNA, FLJ93349, Homo sapiens radixin (RDX), mRNA
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 583 aa
68.6 kDa 		No 0
RDX-002
ENSP00000384136
ENST00000405097
P35241 [Direct mapping]
Radixin
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019904 [protein domain specific binding]
GO:0030027 [lamellipodium]
GO:0030033 [microvillus assembly]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032420 [stereocilium]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0043209 [myelin sheath]
GO:0044822 [poly(A) RNA binding]
GO:0045176 [apical protein localization]
GO:0045177 [apical part of cell]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 604 aa
71 kDa 		No 0
RDX-003
ENSP00000433580
ENST00000528900
P35241 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 257 aa
29.7 kDa 		No 0
RDX-004
ENSP00000436277
ENST00000530301
P35241 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 200 aa
23.4 kDa 		No 0
RDX-006
ENSP00000432112
ENST00000528498
P35241 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 604 aa
71 kDa 		No 0
RDX-010
ENSP00000432572
ENST00000533991
E9PQ82 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
 116 aa
13.5 kDa 		No 0
RDX-012
ENSP00000431560
ENST00000534683
E9PKN5 [Direct mapping]
Radixin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
Show all
 51 aa
6 kDa 		No 0
RDX-014
ENSP00000437140
ENST00000532118
E9PNV3 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
 148 aa
17.3 kDa 		No 0
RDX-201
ENSP00000445826
ENST00000544551
P35241 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 447 aa
52.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.