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FDX1

GENERAL INFORMATION

Gene name

 FDX1

Gene description

 Ferredoxin 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in adrenal gland and Leydig cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041630 , HPA062087
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and stomach cancer (favourable).
Renal cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041630
HPA062087

GENE INFORMATION

Gene name

 FDX1 (HGNC Symbol)

Synonyms

 ADX, FDX

Description

 Ferredoxin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q22.3

Chromosome location (bp)

 110429883 - 110464881

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137714 (version 83.38)

Entrez gene

 2230

UniProt

 P10109 (UniProt - Evidence at protein level)

neXtProt

 NX_P10109

Antibodypedia

 FDX1 antibodies

PROTEIN BROWSER
FDX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FDX1-001
ENSP00000260270
ENST00000260270
P10109 [Direct mapping]
Adrenodoxin, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006700 [C21-steroid hormone biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0009055 [electron carrier activity]
GO:0016125 [sterol metabolic process]
GO:0042446 [hormone biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0051536 [iron-sulfur cluster binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
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 184 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.