Expression of FXYD2 in cancer - Summary

GENERAL INFORMATION
Gene name	FXYD2
Gene description	FXYD domain containing ion transport regulator 2
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (renal cancer)
HPA (cell line):	Group enriched (MOLT-4, RPTEC TERT1)
HPA (normal tissue):	Group enriched (gallbladder, kidney, salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in distal renal tubules, bile duct cells, glandular cells in salivary gland, gallbladder and exocrine pancreas.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA068838
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA068838

GENE INFORMATION
Gene name	FXYD2 (HGNC Symbol)
Synonyms	ATP1G1, HOMG2, MGC12372
Description	FXYD domain containing ion transport regulator 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	117800844 - 117828698
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137731 (version 83.38)
Entrez gene	486
UniProt	P54710 (UniProt - Evidence at protein level)
neXtProt	NX_P54710
Antibodypedia	FXYD2 antibodies

PROTEIN BROWSER

FXYD2-001	FXYD2-002	FXYD2-004	FXYD2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FXYD2-001 ENSP00000260287 ENST00000260287	P54710 [Direct mapping] Sodium/potassium-transporting ATPase subunit gamma Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005216 [ion channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1990573 [potassium ion import across plasma membrane] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	64 aa 7.4 kDa	No	1
FXYD2-002 ENSP00000292079 ENST00000292079	P54710 [Direct mapping] Sodium/potassium-transporting ATPase subunit gamma Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005215 [transporter activity] GO:0005216 [ion channel activity] GO:0005391 [sodium:potassium-exchanging ATPase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0042127 [regulation of cell proliferation] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1990573 [potassium ion import across plasma membrane] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	66 aa 7.3 kDa	No	1
FXYD2-004 ENSP00000432430 ENST00000528014	P54710 [Direct mapping] Sodium/potassium-transporting ATPase subunit gamma Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005216 [ion channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1990573 [potassium ion import across plasma membrane] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	64 aa 7.4 kDa	No	1
FXYD2-005 ENSP00000436414 ENST00000532119	P54710 [Direct mapping] Sodium/potassium-transporting ATPase subunit gamma Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005216 [ion channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1990573 [potassium ion import across plasma membrane] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	64 aa 7.4 kDa	No	1