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ALKBH8

GENERAL INFORMATION

Gene name

 ALKBH8

Gene description

 AlkB homolog 8, tRNA methyltransferase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA038724 , HPA038725 , HPA061514
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038724
HPA038725
HPA061514

GENE INFORMATION

Gene name

 ALKBH8 (HGNC Symbol)

Synonyms

 MGC10235, TRM9, TRMT9

Description

 AlkB homolog 8, tRNA methyltransferase (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q22.3

Chromosome location (bp)

 107502726 - 107565746

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137760 (version 83.38)

Entrez gene

 91801

UniProt

 Q96BT7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96BT7

Antibodypedia

 ALKBH8 antibodies

PROTEIN BROWSER
ALKBH8-001
ALKBH8-002
ALKBH8-003
ALKBH8-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALKBH8-001
ENSP00000415885
ENST00000428149
Q96BT7 [Direct mapping]
Alkylated DNA repair protein alkB homolog 8
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0002098 [tRNA wobble uridine modification]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006400 [tRNA modification]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008033 [tRNA processing]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016300 [tRNA (uracil) methyltransferase activity]
GO:0016491 [oxidoreductase activity]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0030488 [tRNA methylation]
GO:0055114 [oxidation-reduction process]
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 664 aa
75.2 kDa 		No 0
ALKBH8-002
ENSP00000374219
ENST00000389568
Q96BT7 [Direct mapping]
Alkylated DNA repair protein alkB homolog 8
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0002098 [tRNA wobble uridine modification]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006400 [tRNA modification]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008033 [tRNA processing]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016300 [tRNA (uracil) methyltransferase activity]
GO:0016491 [oxidoreductase activity]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0030488 [tRNA methylation]
GO:0055114 [oxidation-reduction process]
Show all
 664 aa
75.2 kDa 		No 0
ALKBH8-003
ENSP00000391225
ENST00000429370
Q96BT7 [Direct mapping]
Alkylated DNA repair protein alkB homolog 8
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0002098 [tRNA wobble uridine modification]
GO:0003676 [nucleic acid binding]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006400 [tRNA modification]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016300 [tRNA (uracil) methyltransferase activity]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0030488 [tRNA methylation]
GO:0055114 [oxidation-reduction process]
Show all
 224 aa
25.7 kDa 		No 0
ALKBH8-005
ENSP00000397673
ENST00000417449
Q96BT7 [Direct mapping]
Alkylated DNA repair protein alkB homolog 8
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0002098 [tRNA wobble uridine modification]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006400 [tRNA modification]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008033 [tRNA processing]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016300 [tRNA (uracil) methyltransferase activity]
GO:0016491 [oxidoreductase activity]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0030488 [tRNA methylation]
GO:0055114 [oxidation-reduction process]
Show all
 667 aa
75.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.