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UNC13C

GENERAL INFORMATION

Gene name

 UNC13C

Gene description

 Unc-13 homolog C (C. elegans)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Group enriched (Karpas-707, U-266/70)
HPA (normal tissue):Group enriched (cerebral cortex, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA041516
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041516

GENE INFORMATION

Gene name

 UNC13C (HGNC Symbol)

Synonyms

 DKFZp547H074, Munc13-3

Description

 Unc-13 homolog C (C. elegans) (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q21.3

Chromosome location (bp)

 54012904 - 54633414

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137766 (version 83.38)

Entrez gene

 440279

UniProt

 Q8NB66 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8NB66

Antibodypedia

 UNC13C antibodies

PROTEIN BROWSER
UNC13C-001
UNC13C-002
UNC13C-003
UNC13C-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UNC13C-001
ENSP00000260323
ENST00000260323
Q8NB66 [Direct mapping]
Protein unc-13 homolog C
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0007268 [synaptic transmission]
GO:0019992 [diacylglycerol binding]
GO:0030054 [cell junction]
GO:0035556 [intracellular signal transduction]
GO:0042734 [presynaptic membrane]
GO:0046872 [metal ion binding]
GO:0048786 [presynaptic active zone]
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 2214 aa
250.9 kDa 		No 0
UNC13C-002
ENSP00000443886
ENST00000539562
A0A0C4DGH4 [Direct mapping]
HCG38864; Protein unc-13 homolog C
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 135 aa
15.5 kDa 		No 0
UNC13C-003
ENSP00000456350
ENST00000560537
H3BRP8 [Direct mapping]
Protein unc-13 homolog C
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Predicted intracellular proteins
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 20 aa
2.3 kDa 		No 0
UNC13C-005
ENSP00000453018
ENST00000559093
H0YL13 [Direct mapping]
Protein unc-13 homolog C
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Predicted intracellular proteins
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GO:0007268 [synaptic transmission]
GO:0019992 [diacylglycerol binding]
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 179 aa
20.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.