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CASC5

GENERAL INFORMATION

Gene name

 CASC5

Gene description

 Cancer susceptibility candidate 5

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues, most abundant in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA026624
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026624

GENE INFORMATION

Gene name

 CASC5 (HGNC Symbol)

Synonyms

 AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Spc7

Description

 Cancer susceptibility candidate 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 40594020 - 40664342

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137812 (version 83.38)

Entrez gene

 57082

UniProt

 Q8NG31 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NG31

Antibodypedia

 CASC5 antibodies

PROTEIN BROWSER
CASC5-001
CASC5-002
CASC5-005
CASC5-006
CASC5-008
CASC5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASC5-001
ENSP00000382576
ENST00000399668
Q8NG31 [Direct mapping]
Protein CASC5
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0001669 [acrosomal vesicle]
GO:0001675 [acrosome assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010923 [negative regulation of phosphatase activity]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0034501 [protein localization to kinetochore]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0071173 [spindle assembly checkpoint]
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 2316 aa
262.6 kDa 		No 0
CASC5-002
ENSP00000335463
ENST00000346991
Q8NG31 [Direct mapping]
Protein CASC5
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0001669 [acrosomal vesicle]
GO:0001675 [acrosome assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0010923 [negative regulation of phosphatase activity]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0034501 [protein localization to kinetochore]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0071173 [spindle assembly checkpoint]
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 2342 aa
265.4 kDa 		No 0
CASC5-005
ENSP00000454087
ENST00000528975
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 7 aa
0.9 kDa 		No 0
CASC5-006
ENSP00000454002
ENST00000532056
A0A0G2JL96 [Direct mapping]
Protein CASC5
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 10 aa
1.3 kDa 		No 0
CASC5-008
ENSP00000436851
ENST00000532406
H0YEY7 [Direct mapping]
Protein CASC5
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 193 aa
22.3 kDa 		No 0
CASC5-201
ENSP00000432654
ENST00000527044
E9PPJ1 [Direct mapping]
Protein CASC5
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 1746 aa
195.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.