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PAK6

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GENERAL INFORMATION

Gene name

 PAK6

Gene description

 P21 protein (Cdc42/Rac)-activated kinase 6

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & nucleoli (fibrillar center). In addition localized to the cell junctions. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Cell line enhanced (HaCaT, CACO-2, hTCEpi)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nucleoli fibrillar center (approved)

Additional location

 In addition localized to the Cell Junctions (uncertain)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA031124
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, CACO-2, hTCEpi)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & nucleoli (fibrillar center). In addition localized to the cell junctions. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Nucleus (supported), Nucleoli fibrillar center (approved)

Additional location

 Cell Junctions (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA031124 A-431 Nucleus
Cell Junctions
HPA031124 CACO-2 Nucleus
Nucleoli fibrillar center
Cell Junctions
HPA031124 U-2 OS Nucleus
Nucleoli fibrillar center

GENE INFORMATION

Gene name

 PAK6 (HGNC Symbol)

Synonyms

 PAK5

Description

 P21 protein (Cdc42/Rac)-activated kinase 6 (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 40238759 - 40277487

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137843 (version 83.38)

Entrez gene

 56924

UniProt

 Q9NQU5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQU5

Antibodypedia

 PAK6 antibodies

PROTEIN BROWSER
«
PAK6-001
PAK6-002
PAK6-003
PAK6-004
PAK6-005
PAK6-006
PAK6-007
PAK6-008
PAK6-009
PAK6-010
PAK6-011
PAK6-012
PAK6-013
PAK6-014
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAK6-001
ENSP00000260404
ENST00000260404
Q9NQU5 [Direct mapping]
Serine/threonine-protein kinase PAK 6
A0A024R9Q4 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 681 aa
74.9 kDa 		No 0
PAK6-002
ENSP00000409465
ENST00000455577
Q9NQU5 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 636 aa
69.8 kDa 		No 0
PAK6-003
ENSP00000453858
ENST00000560346
Q9NQU5 [Direct mapping]
Serine/threonine-protein kinase PAK 6
A0A024R9Q4 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 681 aa
74.9 kDa 		No 0
PAK6-004
ENSP00000439597
ENST00000542403
Q9NQU5 [Direct mapping]
Serine/threonine-protein kinase PAK 6
A0A024R9Q4 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 681 aa
74.9 kDa 		No 0
PAK6-005
ENSP00000453520
ENST00000561230
H0YM99 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 105 aa
12 kDa 		No 0
PAK6-006
ENSP00000453407
ENST00000558055
H0YLZ9 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 122 aa
13.9 kDa 		No 0
PAK6-007
ENSP00000452737
ENST00000558878
H0YKB6 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 58 aa
6.8 kDa 		No 0
PAK6-008
ENSP00000452647
ENST00000558183
H0YK38 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 74 aa
8.6 kDa 		No 0
PAK6-009
ENSP00000453005
ENST00000560806
H0YL02 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 20 aa
2.3 kDa 		No 0
PAK6-010
ENSP00000452708
ENST00000559617
H0YK91 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 112 aa
12.8 kDa 		No 0
PAK6-011
ENSP00000453721
ENST00000558106
H0YMS4 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 123 aa
14 kDa 		No 0
PAK6-012
ENSP00000453057
ENST00000560684
H0YL47 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 71 aa
8.3 kDa 		No 0
PAK6-013
ENSP00000452686
ENST00000559139
H0YK74 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 109 aa
12.5 kDa 		No 0
PAK6-014
ENSP00000453021
ENST00000560669
H0YL16 [Direct mapping]
Serine/threonine-protein kinase PAK 6
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 284 aa
30.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.