Expression of DUOX1 in cancer - Summary

GENERAL INFORMATION
Gene name	DUOX1
Gene description	Dual oxidase 1
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Cell line enhanced (HaCaT, hTCEpi, RT4)
HPA (normal tissue):	Tissue enhanced (skin, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in epithelial cells, most abundant in gastrointestinal tract thyroid gland and respiratory tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Antibody staining in a subset of structures are not annotated as epithelial cells, view images.
Reliability score	Approved based on 1 antibody. HPA023544
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA023544

GENE INFORMATION
Gene name	DUOX1 (HGNC Symbol)
Synonyms	LNOX1, NOXEF1, THOX1
Description	Dual oxidase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
Chromosome	15
Cytoband	q21.1
Chromosome location (bp)	45129933 - 45165576
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137857 (version 83.38)
Entrez gene	53905
UniProt	Q9NRD9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRD9
Antibodypedia	DUOX1 antibodies

PROTEIN BROWSER

DUOX1-001	DUOX1-005	DUOX1-006	DUOX1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DUOX1-001 ENSP00000373689 ENST00000389037	Q9NRD9 [Direct mapping] Dual oxidase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016324 [apical plasma membrane] GO:0016491 [oxidoreductase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0020037 [heme binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042335 [cuticle development] GO:0042446 [hormone biosynthetic process] GO:0042554 [superoxide anion generation] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0050661 [NADP binding] GO:0050665 [hydrogen peroxide biosynthetic process] GO:0051591 [response to cAMP] GO:0055114 [oxidation-reduction process] Show all	1551 aa 177.2 kDa	Yes	7
DUOX1-005 ENSP00000454065 ENST00000561166	Q9NRD9 [Direct mapping] Dual oxidase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016324 [apical plasma membrane] GO:0016491 [oxidoreductase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0020037 [heme binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042335 [cuticle development] GO:0042446 [hormone biosynthetic process] GO:0042554 [superoxide anion generation] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0050661 [NADP binding] GO:0050665 [hydrogen peroxide biosynthetic process] GO:0051591 [response to cAMP] GO:0055114 [oxidation-reduction process] Show all	1197 aa 137.6 kDa	Yes	7
DUOX1-006 ENSP00000317997 ENST00000321429	Q9NRD9 [Direct mapping] Dual oxidase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016324 [apical plasma membrane] GO:0016491 [oxidoreductase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0020037 [heme binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042335 [cuticle development] GO:0042446 [hormone biosynthetic process] GO:0042554 [superoxide anion generation] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0050661 [NADP binding] GO:0050665 [hydrogen peroxide biosynthetic process] GO:0051591 [response to cAMP] GO:0055114 [oxidation-reduction process] GO:0072593 [reactive oxygen species metabolic process] Show all	1551 aa 177.2 kDa	Yes	7
DUOX1-007 ENSP00000454121 ENST00000558322	H0YNR5 [Direct mapping] Dual oxidase 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 5 kDa	Yes	0