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BCL2L10

GENERAL INFORMATION

Gene name

 BCL2L10

Gene description

 BCL2-like 10 (apoptosis facilitator)

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin)
GTEx:Mixed
FANTOM5:Tissue enhanced (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most abundant in liver and kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA042222
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)

GENE INFORMATION

Gene name

 BCL2L10 (HGNC Symbol)

Synonyms

 BCL-B, Boo, Diva

Description

 BCL2-like 10 (apoptosis facilitator) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 52109263 - 52112775

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137875 (version 83.38)

Entrez gene

 10017

UniProt

 Q9HD36 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HD36

Antibodypedia

 BCL2L10 antibodies

PROTEIN BROWSER
BCL2L10-001
BCL2L10-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCL2L10-001
ENSP00000260442
ENST00000260442
Q9HD36 [Direct mapping]
Bcl-2-like protein 10
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007283 [spermatogenesis]
GO:0007292 [female gamete generation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
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 204 aa
23.2 kDa 		No 1
BCL2L10-002
ENSP00000453562
ENST00000561198
H0YMD5 [Direct mapping]
Bcl-2-like protein 10
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0005741 [mitochondrial outer membrane]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
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 241 aa
26.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.