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BCAR3

GENERAL INFORMATION

Gene name

 BCAR3

Gene description

 Breast cancer anti-estrogen resistance 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA014858
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Rectum
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 BCAR3 (HGNC Symbol)

Synonyms

 NSP2, SH2D3B

Description

 Breast cancer anti-estrogen resistance 3 (HGNC Symbol)

Entrez gene summary

 Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

 1

Cytoband

 p22.1

Chromosome location (bp)

 93561786 - 93847150

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137936 (version 83.38)

Entrez gene

 8412

UniProt

 O75815 (UniProt - Evidence at protein level)

neXtProt

 NX_O75815

Antibodypedia

 BCAR3 antibodies

PROTEIN BROWSER
BCAR3-001
BCAR3-002
BCAR3-003
BCAR3-004
BCAR3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCAR3-001
ENSP00000260502
ENST00000260502
O75815 [Direct mapping]
Breast cancer anti-estrogen resistance protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0042493 [response to drug]
GO:0043547 [positive regulation of GTPase activity]
Show all
 825 aa
92.6 kDa 		No 0
BCAR3-002
ENSP00000359263
ENST00000370243
O75815 [Direct mapping]
Breast cancer anti-estrogen resistance protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0042493 [response to drug]
GO:0043547 [positive regulation of GTPase activity]
Show all
 825 aa
92.6 kDa 		No 0
BCAR3-003
ENSP00000359264
ENST00000370244
O75815 [Direct mapping]
Breast cancer anti-estrogen resistance protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002089 [lens morphogenesis in camera-type eye]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042493 [response to drug]
GO:0043547 [positive regulation of GTPase activity]
Show all
 825 aa
92.6 kDa 		No 0
BCAR3-004
ENSP00000359267
ENST00000370247
O75815 [Direct mapping]
Breast cancer anti-estrogen resistance protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0042493 [response to drug]
GO:0043547 [positive regulation of GTPase activity]
Show all
 734 aa
82.4 kDa 		No 0
BCAR3-201
ENSP00000441343
ENST00000539242
O75815 [Direct mapping]
Breast cancer anti-estrogen resistance protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0042493 [response to drug]
GO:0043547 [positive regulation of GTPase activity]
Show all
 501 aa
55.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.