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CLCA2

GENERAL INFORMATION

Gene name

 CLCA2

Gene description

 Chloride channel accessory 2

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus, skin)
GTEx:Tissue enhanced (esophagus, skin, vagina)
FANTOM5:Group enriched (cervix, uterine, esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in squamous epithelia and mammary gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA047192
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, tonsil)

GENE INFORMATION

Gene name

 CLCA2 (HGNC Symbol)

Synonyms

 CLCRG2

Description

 Chloride channel accessory 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p22.3

Chromosome location (bp)

 86424086 - 86456558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137975 (version 83.38)

Entrez gene

 9635

UniProt

 Q9UQC9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQC9

Antibodypedia

 CLCA2 antibodies

PROTEIN BROWSER
CLCA2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLCA2-001
ENSP00000359596
ENST00000370565
Q9UQC9 [Direct mapping]
Calcium-activated chloride channel regulator 2 Calcium-activated chloride channel regulator 2, 109 kDa form Calcium-activated chloride channel regulator 2, 35 kDa form
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005254 [chloride channel activity]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006821 [chloride transport]
GO:0007155 [cell adhesion]
GO:0008237 [metallopeptidase activity]
GO:0009925 [basal plasma membrane]
GO:0015276 [ligand-gated ion channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
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 943 aa
103.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.