Tissue expression of DNASE2B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DNASE2B
Gene description	Deoxyribonuclease II beta
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (salivary gland)
GTEx:	Tissue enhanced (salivary gland)
FANTOM5:	Tissue enriched (salivary gland)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION
Gene name	DNASE2B (HGNC Symbol)
Synonyms	DLAD
Description	Deoxyribonuclease II beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband
Chromosome location (bp)	84398532 - 84415018
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000137976 (version 83.38)
Entrez gene	58511
UniProt	Q8WZ79 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WZ79
Antibodypedia	DNASE2B antibodies

PROTEIN BROWSER

DNASE2B-001	DNASE2B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNASE2B-001 ENSP00000359699 ENST00000370665	Q8WZ79 [Direct mapping] Deoxyribonuclease-2-beta Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004520 [endodeoxyribonuclease activity] GO:0004531 [deoxyribonuclease II activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0006259 [DNA metabolic process] GO:0006309 [apoptotic DNA fragmentation] Show all	361 aa 41.7 kDa	Yes	0
DNASE2B-002 ENSP00000359696 ENST00000370662	Q8WZ79 [Direct mapping] Deoxyribonuclease-2-beta Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004531 [deoxyribonuclease II activity] GO:0005764 [lysosome] GO:0006259 [DNA metabolic process] GO:0006309 [apoptotic DNA fragmentation] Show all	153 aa 17.8 kDa	No	0